In this work, CFD results at different scales are used to aid in the scale up of crystal wet milling processes. CFD simulations were performed to simulate different scale mixers. In addition, wet milling studies were conducted at the bench scale to complement the CFD results and predict wet milling performance in larger scale mixers. The flow properties in a batch Silverson L4R rotor-stator mixer at 4000 and 6000 rpm were investigated. A hybrid technique was developed. The new method is computationally efficient compared with the standard sliding mesh method.
Author:- Yang, Meng